A STUDY OF TERMINATION OF TOLERANCE TO BSA WITH DNP-BSA IN RABBITS - RELATIVE AFFINITIES OF ANTIBODIES FOR IMMUNIZING AND PARALYSING ANTIGENS

  • 1 January 1967
    • journal article
    • research article
    • Vol. 13  (2) , 147-+
Abstract
Rabbits rendered immuno-logically tolerant to BSA produced antibodies capable of precipitating BSA following immunization with DNP-BSA. Antigen binding studies using purified ''anti-BSA'' antibodies produced by tolerant animals indicated that these antibodies bound DNP-BSA with far greater avidity than BSA. It was concluded that a true termination of tolerance had not occurred. The implications of the results with regard to induction of antibody formation and of tolerance are discussed.