Effect ofdl-2(p-Aminophenyl)-2-phenylethylamine on Adrenocortical Function in Cushing's Syndrome Due to Nontumorous Adrenocortical Hyperfunction1

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Abstract
Dl-2 (p-Aminophenyl)-2-phenylethylamine (SK&F-12185), a new adrenocortical blocking agent, was given to 3 patients with Cushing's syndrome due to nontumorous adrenocortical hyperfunction. The drug caused a rise in the urinary titer of neutral 17-ketosteroids, testosterone and 17-hydroxycorticoids. It induced a fall in the adrenal secretory rate of cortisol and in urinary tetrahydrocortisol and a rise in the adrenal secretory rate of 11-deoxycortisol and of the urinary excretion of tetrahydro S. Presumably one of the sites of action of the drug is interference with 11β-hydroxylation. In one subject treated with SK&F-12185 the urinary aldosterone titer failed to rise when he was placed on a low salt diet, suggestive of interference by the drug with aldosterone production. In one subject marked clinical improvement was noted. In a second only modest amelioration was observed. Drug fever prevented prolonged observation in the third subject, although a decrease in the urinary titers of tetrahydrocortisol suggested the effectiveness of the drug in decreasing cortisol production.

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