Studies on a novel cytocidal antibiotic, trienomycin A. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics.
- 1 January 1985
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 38 (6) , 699-705
- https://doi.org/10.7164/antibiotics.38.699
Abstract
A new antibiotic, trienomycin A, was isolated from the culture broth of Streptomyces sp. no. 83-16. The physico-chemical characteristics of the antibiotic suggested that it belongs to the group of ansamycin antibiotics with a triene moiety in the molecule. The molecular formula of trienomycin A is C36H50N2O7 (MW 622). The antibiotic possesses potent cytocidal activity against HeLa S3 and PLC hepatoma cells at concentration of 0.1 and 0.01 .mu.g/ml (IC50 value), respectively. Trienomycin A showed no antimicrobial activity against the bacteria, fungi and yeasts examined, with the exception of weak activity vs. Piricularia oryzae at a concentration of 1000 .mu.g/ml.This publication has 4 references indexed in Scilit:
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