Validity of the Bromsulphalein (BSP) Method for Estimating Hepatic Blood Flow

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Abstract
The accuracy of application of the Fick principle for extimating hepatic blood flow by BSP extraction was tested in dogs by comparing A-V differences across several vascular beds, and by observing the rate of dye disappearance during temporary occlusion of the hepatic circulation. The results indicate that approx. 11% of the administered BSP is removed by extrahepatic tissue, and it may be concluded that this extrahepatic removal will introduce a positive error of comparable magnitude in the estimation of effective hepatic blood flow.