THE EFFECTS OF AMINOPTERIN AND ESTROGEN ON THE PHOSPHATE METABOLISM OF RAT UTERUS1

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Abstract
Estrogen caused an increase in the nucleic acids, phospholipids, acid-soluble phosphates, and protein nitrogen of uteri of castrate rats. Folic acid deficiency induced by aminopterin inhibited this increase. Estrogen caused an increase in the uptake of radioactive P in the nucleic acid and phospholipid fraction but not in the other fractions. Aminopterin inhibited the increased uptake by the nucleic acids and stimulated the incorporation into the phospho -proteins. Estrogen increased the activity of both alkaline and acid phosphatase in the uterus. Aminopterin inhibited the increase in acid phosphatase but not alkaline phosphatase activity.