Aminopterin and Response of Frog Oviducts to Estradiol. II. Histological Studies and Mitotic Counts.
- 1 July 1949
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 71 (3) , 461-463
- https://doi.org/10.3181/00379727-71-17224
Abstract
Both macro-scopically and microscopically, the oviducts of frogs receiving aminopterin (4-amino-pteroglutamic acid) failed to respond to the growth stimulating action of estradiol, but a significantly greater number of mitotic figures were visible in the ducts. The folic acid antagonists may exert their growth-inhibiting action by interfering with folic acid utilization in the organism, with a consequent reduction in nucleic acid synthesis and a retardation of the rate of cell division.Keywords
This publication has 6 references indexed in Scilit:
- Inhibition of Development of Sarcoma 180 by 4-Amino-N10-Methyl Pteroylglutamic Acid.Experimental Biology and Medicine, 1949
- Studies on the chemotherapy of leukemia.II. The effect of 4-amino-pteroylglutamic acid and 4-amino-n10-methyl-pteroylglutamic acid on transplanted mouse leukemiaCancer, 1949
- THE INFLUENCE OF PTEROYLGLUTAMIC ACID ON NUCLEIC ACID SYNTHESIS IN LACTOBACILLUS CASEIJournal of Biological Chemistry, 1948
- 4-Amino Pteroylglutamic Acid (Aminopterin), Pteroylglutamic (Folic) Acid, and Response of Frogs, Rana clamitans, to Estrogens.Experimental Biology and Medicine, 1948
- Substitution of Thymine for “Folic Acid” in the Nutrition of Lactic Acid BacteriaJournal of Bacteriology, 1944
- On the Synthesis of Cleavage ChromosomesProceedings of the National Academy of Sciences, 1940