Bone-Resorbing Activity in Supernatants from Lymphoid Cell Lines

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Abstract
To study the pathogenesis of osteolytic lesions and hypercalcemia in neoplastic disease, supernatant fluids of cultured lymphoid cell lines were tested for their ability to stimulate bone resorption in vitro. Lines from patients with myeloma, Burkitt's lymphoma, and malignant lymphoma secreted a potent bone-resorbing material. Four lines from normal subjects or patients with other neoplasms did not have this activity.