THE EFFECT OF TOLBUTAMIDE (RASTINON) ON THE LEVELS OF GLUCOSE AND INORGANIC PHOSPHORUS OF BLOOD IN NORMOTHERMIC AND HYPOTHERMIC RATS

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Abstract
Blood sugar, inorganic phosphorus, and hematocrit values were measured in normothermic and hypothermic (25 °C) fasted rats injected intra-arterially with tolbutamide (Rastinon) and a control solution. Doses of 12.5, 25, 50, and 100 mg/kg body weight of tolbutamide led to hypoglycemia in the normothermic rats, whereas doses of 25 and 200 mg/kg tolbutamide had no effect on the blood sugar levels of hypothermic rats. Doses of 25, 50, 100, and 200 mg/kg caused the blood inorganic phosphorus levels to fall, and in the so-called "normothermic" rats the colonic temperature was reduced. A dose of 200 mg/kg injected intra-arterially led to a fall in the inorganic phosphorus levels of blood in hypothermic rats.