Abstract
The selection of a criterion, index, or output to measure, when an experiment is planned will influence not only the conduct of the study, but also the findings and the generalizations that can properly be made on the basis of the results. Guidelines for making such selections among psychobiological, sensorimotor, and performance measurement domains are presented, based on the summary findings of research in four areas: the behavioral effects of (1) occupational exposure to inorganic lead; (2) exposure to carbon monoxide; (3) sleep loss; and (4) infectious disease. Three dimensions that must be considered in order to optimize the selection are: (1) the purpose, immediate and distal, of the specific study; (2) the degree of specificity vs. generality of the organismic changes involved; and (3) the desired area(s) of generalization of the results or findings of the study.

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