Tryptoline Formation by a Preparation from Brain with 5-Methyltetrahydrofolic Acid and Tryptamine
- 7 March 1975
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 187 (4179) , 853-855
- https://doi.org/10.1126/science.234627
Abstract
An enzymatic preparation from human brain converts tryptamine to tryptoline (9H-1,2,3,4-tetrahydropyrido[3,4-b]indole) in the presence of 5-methyltetrahydrofolic acid. Similarly, N-methyltryptamine and 5-hydroxytryptamine yield 1-methyltryptoline and 5-hydroxytryptoline, respectively. Neither in vitro nor in vivo formation of these compounds by human tissues has been described.Keywords
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