Targeted integration of baboon endogenous virus in the BEVI locus on human chromosome 6
- 1 January 1983
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 301 (5896) , 129-132
- https://doi.org/10.1038/301129a0
Abstract
The infection of cultured human cells with baboon endogenous virus (BEV) frequently leads to an association of viral DNA with a specific genetic locus (termed BEVI, for baboon endogenous virus infection) on chromosome 6. Restriction endonuclease digestion of DNA from BEV-infected human cells and their derived somatic cell clones frequently revealed a common cellular DNA sequence in the proximity of one of the junctions between cellular DNA and the integrated virus. We propose that a short cellular DNA sequence, repeated on chromosome 6 and separated by unique DNA sequences, presents a high-affinity target for the integration of BEV in human cells.Keywords
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