Nuclear analogs of β-lactam antibiotics. XII. 2-Oxodesthiocephalosporins
- 15 March 1979
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 57 (6) , 614-625
- https://doi.org/10.1139/v79-100
Abstract
Epoxidation of Δ2-1-carbacephems 2 followed by base treatment gave the allylic alcohols 4. Oxidation of 4 gave the 2-keto-Δ3-carbacephem 9 which could be reduced to the isomeric allylic alcohol 7. Conversion of these intermediates to a series of biologically active cephalosporin analogs 13g–l and 14 is described.This publication has 2 references indexed in Scilit:
- Nuclear analogs of β-lactam antibiotics. X. Synthesis of 2-substituted desthiocephalosporinsCanadian Journal of Chemistry, 1979
- Nuclear analogs of β-lactam antibiotics. XI. Synthesis of 3-methyl-7-β-(phenoxyacetamido)-Δ3-desthiocephem-4-carboxylic acidCanadian Journal of Chemistry, 1979