Conversion of Δ5-Androstene-3β,16α,17β-Triol to Estriol by Human Placenta1
- 1 September 1958
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 63 (3) , 392-394
- https://doi.org/10.1210/endo-63-3-392
Abstract
The in vitro conversion of Δ5-androstene-3β,16α,17β-triol to estriol by human placental preparations has been described. Estriol was characterized by determining several physical constants of the isolated product and its methyl ether, as well as by a positive Bachman reaction. This unique conversion suggests a biological role for the neutral 16-hydroxylated steroids previously isolated from human urine and lends support to the concept of a biosynthetic pathway for estriol not involving known estrogen precursors.Keywords
This publication has 7 references indexed in Scilit:
- ISOLATION AND ESTIMATION OF »FREE« OESTROGENS IN HUMAN PLACENTAEActa Endocrinologica, 1956
- A chemical method for the determination of oestriol, oestrone and oestradiol in human urineBiochemical Journal, 1955
- INTERACTION OF ESTROGENS ON UTERINE GROWTH*Journal of Clinical Endocrinology & Metabolism, 1954
- THE QUANTITATIVE SEPARATION OF ESTROGENS BY PAPER PARTITION CHROMATOGRAPHYJournal of Biological Chemistry, 1953
- STUDIES IN STEROID METABOLISM .18. ISOLATION OF 3 NEW STEROID TRIOLS FROM HUMAN URINE1953
- Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissuesBiochemical Journal, 1952
- An Androstenetriol in Normal Human UrineNature, 1944