EVIDENCE THAT INHIBITION OF ERYTHROPOIESIS IS IMPORTANT IN THE ANEMIA OF CHRONIC-RENAL-FAILURE

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 97  (2) , 170-178
Abstract
Previous studies have documented that serum from patients with chronic renal failure is capable of inhibiting erythropoiesis in vitro. Few data link this finding with the pathophysiology of the anemia of uremia. Hematocrits from uremic patients were correlated with the degree to which serum from these patients inhibited erythropoiesis, using 2 different in vitro systems. Studies were conducted on patients receiving hemodialysis and patients with varying degrees of uremia not receiving dialysis and serial studies were performed on patients in whom long-term hemodialysis was initiated. Study of patients with varying degrees of renal failure showed that levels of inhibitor developed and increased as renal failure worsened and the hematocrit level fell. A fall in inhibitor level was found in those patients who had an increase in hematocrit after long-term hemodialysis. Inhibition of erythropoiesis evidently is involved in the anemia of chronic renal failure.