Synthesis of Enantiopure α‘-Amino α,β-Epoxy Ketones from α‘-Amino Bromomethyl Ketones
- 17 June 1999
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 64 (14) , 5048-5052
- https://doi.org/10.1021/jo982435z
Abstract
Preparation of enantiomerically pure α'-amino α,β-epoxy ketones 2 in an efficient synthesis starting from α'-amino bromomethyl ketones 5 and the obtention of amino diepoxido 10a as synthetic application of 2 are described. We also report the generalization of the synthesis of 1-aminoalkyl halomethyl ketones to their bromo derivatives.Keywords
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