MANIPULATION OF METASTASIS AND TUMOUR GROWTH BY TRANSFECTION WITH HISTOCOMPATIBILITY CLASS I GENES
- 2 April 1986
- journal article
- Published by Wiley in International Journal of Immunogenetics
- Vol. 13 (2-3) , 153-157
- https://doi.org/10.1111/j.1744-313x.1986.tb01096.x
Abstract
Approximately 50% of fibrosarcomas induced with methylcholanthrene A were found to be defective in H-2 expression. In tumours which lack H-2K antigens, H-2 gene transfection was used to restore H-2K expression. The de novo expression of H-2K reduced tumorigenicity and abolished the formation of metastases in syngeneic mice. Expression of H-2K seems to render the tumour cells immunogenic and leads to effective recognition of the tumour cells by the host immune system.Keywords
This publication has 3 references indexed in Scilit:
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