Evaluation of the carcinogenicity of different preparations of areca nut in mice

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Abstract
Areca nut has been used as a masticatory since antiquity and it is estimated that more than 10% of the world population chews it in a variety of forms. We have evaluated the carcinogenicity of different preparations of areca nut: ripe‐uprocessedsundried nut (R‐UP‐SD), ripe‐processedsundried nut (R‐P‐SD), unripe‐processed‐sundried nut (UR‐P‐SD), ripe‐unprocessed‐sundried‐water‐soaked nut (R‐UP‐SD‐WS) and ripe‐unprocessed‐undried‐water‐soaked nut (R‐UP‐UD‐WS) in mice following diet‐feeding or oral feeding for 12 months. Only unprocessed areca nuts (R‐UP‐SD, R‐UP‐SD‐WS and R‐UP‐UD‐WS), at high doses, displayed a very weak carcinogenicity.