Reading signals on the nucleosome with a new nomenclature for modified histones
- 1 February 2005
- journal article
- Published by Springer Nature in Nature Structural & Molecular Biology
- Vol. 12 (2) , 110-112
- https://doi.org/10.1038/nsmb0205-110
Abstract
The tails of the four core histones are exposed on the nucleosome surface, where they are subject to a variety of enzyme-catalyzed, post-translational modifications. Modifications, singly or in combination, provide a source of information that can be used for signal transduction during ongoing processes, such as transcription, or as heritable epigenetic marks. A nomenclature is presented that allows patterns of histone modification to be clearly and unambiguously specified and that should facilitate discussion of their functional roles.Keywords
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