PATHOGENESIS OF RABIES

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  • 1 January 1963
    • journal article
    • research article
    • Vol. 29  (6) , 803-+
Abstract
The fixed and street strains of rabies virus are ordinarily transmitted from the site of exposure to the central nervous system via the peripheral nerves, but other than nerve transmission may occur in young animals, in highly susceptible species or in animals whose resistance has been altered by trauma or shock. Air-borne infection is occasionally possible. Blood-borne infection in nature is believed to be exceptional and less likely to occur in man, whose resistance to rabies is high, than in animals of species known to be highly susceptible. Evidence of nerve-borne transmission was also observed with herpes simplex virus but not with lympho-cytic choriomeningitis virus or the GD7 and FA strains of mouse encephalomyelitis virus.