Decrease in Reelin and Glutamic Acid Decarboxylase67 (GAD67) Expression in Schizophrenia and Bipolar Disorder
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Open Access
- 1 November 2000
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 57 (11) , 1061-1069
- https://doi.org/10.1001/archpsyc.57.11.1061
Abstract
SCHIZOPHRENIA is presumed to be a disorder of brain cortical function expressing a variable array of devastating psychiatric symptoms. Such florid symptoms contrast with comparatively modest anatomopathological alterations characterized by (1) dilation of cerebral ventricles1; (2) reduction of cortical neuropil, resulting in an apparent increase in cell-packing density2; (3) decrease in apical dendrite spine density on cortical pyramidal neurons3,4; (4) important morphological (axon terminals of chandelier neurons)5 and neurochemical (decrease of glutamic acid decarboxylase67 [GAD67])6-8 alterations of inhibitory γ-aminobutyric acid-ergic (GABAergic) interneurons.Keywords
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