On the Hyperthermia Induced by 2,4-Dinitrophenol

Publisher Website
Google Scholar
Abstract
2,4-Dinitrophenol (20 mg/kg) injected in female Sprague-Dawley rats induces a hyperthermic effect. This effect is not blocked by several adrenergic blocking agents (phentolamine, phenoxibenzamine, chlorpromazine, propranolol, pronethalol) or by [alpha] -methyl-tyrosine, an inhibitor of norepinephrine synthesis. This hyperthermic effect is also present in adrenalectomized, adrenomedullec-tomized and reserpinized rats, pretreated with [alpha]-methyl-tyrosine. The effect of 2,4-dinitrophenol on carbohydrate and free fatty acid metabolism in normal and adrenalectomized rats is also reported in this paper. In these experimental conditions the action of 2,4-dinitrophenol on body temperature of rats is probably not mediated by catecholamine activity.