Stabilisation of collagen by betel nut polyphenols as a mechanism in oral submucous fibrosis
- 1 April 1987
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 43 (4) , 391-393
- https://doi.org/10.1007/bf01940422
Abstract
Treatment of reconstituted collagen fibrils and pieces of rat dermis with the crude extract, purified tannins or (+)-catechin from betel nut (Areca catechu) increases their resistance to both human and bacterial collagenases in a concentration-dependent manner. These tanning agents may stabilise collagen in vivo following damage to the oral epithelium and promote the sub-epithelial fibrosis which occurs in betel nut chewers.This publication has 15 references indexed in Scilit:
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