DESTRUCTION OF REGIONAL LYMPH-NODE METASTASES OF RAT MAMMARY ADENOCARCINOMA 13762A BY TREATMENT WITH CORYNEBACTERIUM-PARVUM

  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (12) , 4522-4526
Abstract
Intratumoral administration of C. parvum [Propionibacterium acnes] to 13762A tumor-bearing rats on day 7 of tumor growth, followed by primary tumor excision on day 20, regularly cured about 40% of the animals and significantly prolonged survival in the remainder. Rats treated by surgery alone on day 7 or day 20 died with metastases to axillary lymph nodes and lungs. Tumor was established in axillary lymph nodes by day 7. Intratumoral injection of C. parvum on day 7 destroyed metastases already established at this site. Growth of tumor in axillary nodes of rats treated but not curved by C. parvum was significantly slower than growth in untreated rats.