The Hemorrhagic Synchorne Complicating Extracorporeal Shunting of Blood: An Experimental Study of its Pathogenesis

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Abstract
Dogs subjected to extracorporeal circulation with a modified D e Wall heart-lung apparatus developed thrombocytopenia and severe deficiency of the antihemophilic factor (AHF). To quantitate this reaction more accurately, a two-stage method of study was devised whereby citrated blood in the first stage was subjected to artificial, oxygenation and then in the second stage, was transfused into recipient dogs. In all cases, depression in AHF and platelets occurred even though fibrinogen remained at high levels. Depression in AHF levels could also be produced by mechanical damage to tissues of the extremities or by the autotransfusion of stored blood. Control transfusion of fresh blood produced no such effects. * This investigation was supported in part by the Research and Development Division, the Office of the Surgeon General, Department of the Army, under Contract No. DA-49-007-MD-612. ** Markle Scholar in Medical Science.