Utilization of the Antihemophilic Factor During Clotting of Canine Blood and Plasma
- 28 February 1951
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 164 (3) , 710-715
- https://doi.org/10.1152/ajplegacy.1951.164.3.710
Abstract
Using prothrombin conversion in canine hemophilic blood as an index of the antihemophilic activity of added normal plasma or serum, the rate of disappearance of AHF (antihemophilic factor) in clotting blood and plasma under varying circumstances was studied. Prothrombin and AHF disappeared at equal rates, each being proportional to the platelet level and available wettable surface. The utilization appeared to depend on the presence of ionic Ca and prothrombin, but to be independent of fibrinogen.Keywords
This publication has 9 references indexed in Scilit:
- Prothrombin Utilization during Clotting: Comparison of Results with the Two-Stage and One-Stage Methods.Experimental Biology and Medicine, 1950
- EFFECT OF BLOOD PLATELETS ON PROTHROMBIN UTILIZATION OF DOG AND HUMAN PLASMASAmerican Journal of Physiology-Legacy Content, 1949
- CANINE HEMOPHILIAThe Journal of Experimental Medicine, 1949
- Clotting Defect in Hemophilia: Deficiency in a Plasma Factor Required for Platelet UtilizationExperimental Biology and Medicine, 1947
- AN IMPROVED METHOD FOR THE DETERMINATION OF PLASMA PROTHROMBIN1946
- DEMONSTRATION OF ANTITHROMBOPLASTIC ACTIVITY IN NORMAL AND HEMOPHILIC PLASMASAmerican Journal of Physiology-Legacy Content, 1943
- A STUDY OF THE CLOTTING DEFECT IN HEMOPHILIAThe Lancet Healthy Longevity, 1939
- HEMOPHILIA. II. SOME PROPERTIES OF A SUBSTANCE OBTAINED FROM NORMAL HUMAN PLASMA EFFECTIVE IN ACCELERATING THE COAGULATION OF HEMOPHILIC BLOODJournal of Clinical Investigation, 1937
- HEMOPHILIA. I. THE ABNORMAL COAGULATION OF THE BLOOD AND ITS RELATION TO THE BLOOD PLATELETSJournal of Clinical Investigation, 1936