Paper Electrophoretic Studies in Mu1tiple Sclerosis

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Abstract
Blood proteins in 22 cases and cerebrospinal fluid proteins in 10 cases of multiple sclerosis were studied by the technique of paper electrophoresis. In the blood serum study, cases were divided into 2 groups representing early and later stages of the disease. Only a trend of deterioration between the 2 groups could be established. No statistical significance could be attached to the differences. The decrease of albumin in the blood serum is considered to be nonspecific for multiple sclerosis, representing rather a general metabolic deterioration. The protein pattern of the cerebrospinal fluid is characterized by significant changes in gamma globulin. These findings confirm our earlier studies where we used a chemical method for determination of gamma globulin. Neurology 3: 410. 1953.