The Susceptibility of Penicillinase-producing Bacteria to Penicillin

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Abstract
NaN3 renders penicillinase-producing organisms more susceptible to penicillin. Organisms not producing the enzyme are not similarily affected. NaN3 does not directly inhibit the activity of the enzyme. The potentiating action is due to suppression of production of penicillinase by growing cultures. A compound of lower toxicity but with comparable activity might be used effectively in conjunction with penicillin to treat infections due to penicillinase-producing staphylococci.