Classification of ??-Lactamases from Branhamella catarrhalis in Relation to Penicillinases Produced by Other Bacterial Species

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Abstract
Branhamella catarrhalis strains resistant to commonly used penicillins, and presently isolated, produce a β-lactamase. Most of these enzymes are chromosomally mediated, but a plasmid-mediated β-lactamase has been described (enzyme BRO-1). With reference to isoelectric points, 7 different enzymes have been identified: 6 chromosomally mediated and 1 plasmid-mediated. Nevertheless, they have many common properties, such as being biosynthesised constitutively but with a low level of production. They have a penicillinasetype profile, and are strongly inhibited by clavulanic acid.