Isopropyl Alcohol, Other Ketogens, and Miscellaneous Agents on Thresholds for Electrical Convulsions and Diphenylhydantoin

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Abstract
The majority of certain compounds tried, and related in chemical structure to acetone, particularly isopropyl alcohol, were found to raise considerably the threshold for electrical convulsions in rats. Isopropyl alcohol increased the cortical depressant efficiency of diphenylhydan-tom without demonstrable motor depression or narcosis. Some other alcohols and certain sugars and organic acids were ineffective. The possible significance of the isopropyl groups (or propanol) for benefits from ketogenic agents in epilepsy and for developing new or improving old antiepileptic agents is discussed.

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