Rapid induction of nucleoside-diphosphate kinase in HeLa S3 cells by human-type interferons
Open Access
- 3 February 1986
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 196 (1) , 145-150
- https://doi.org/10.1016/0014-5793(86)80230-7
Abstract
Nucleoside‐diphosphate (NDP)‐kinase can be considered to be induced by human‐type interferons (HuIFNs) rapidly, since an enzyme increase was detected within 2 h of incubation of HeLa S3 cells with HuIFNs, while incubation with heterologous mouse IFNs had no such effect. The enzyme increase induced by HuIFNs reached a plateau at 6 h after treatment. Actinomycin D (0.5 ) significantly blocked the enzyme increase induced by HuIFNs in the cells. A possible biological role of the enzyme in the IFN‐induced biochemical events is discussed.Keywords
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