Second‐trimester maternal serum immunoreactive inhibin as a marker for fetal Down's syndrome
- 1 October 1992
- journal article
- research article
- Published by Wiley in Prenatal Diagnosis
- Vol. 12 (10) , 801-806
- https://doi.org/10.1002/pd.1970121005
Abstract
We measured immunoreactive inhibin in the maternal serum of 80 pregnancies with a chromosomally normal fetus and ten Down's syndrome pregnancies in the second trimester. The inhibin level in all Down's syndrome pregnancies was above the normal median; the multiple of the normal median (MoM) was 1.9. We found a statistically significant difference between the levels of inhibin in unaffected and affected pregnancies (Kolmogorov–Smirnov test: p <0.002). Using an arbitrarily chosen cut-off of 2.4 MoM, 40 per cent of Down's syndrome and 5 per cent of the normal pregnancies were found. We conclude that immunoreactive inhibin may be useful as a marker for fetal Down's syndrome.Keywords
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