Carcinogenicity Tests of Certain Environmental and Industrial Chemicals23

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Abstract
Fourteen chemicals of varied uses were tested for carcinogenicity by oral administration in male and female Charles River CD rats. Under the conditions of the tests, propane sultone, propylene imine, and ethylenethiourea, in addition to the positive control N-2-fluorenylacetamide, were carcinogenic. Avadex, bis-(2-chloroethyl) ether, the potassium salt of bis(2-hydroxyethyl)dithiocarbamic acid, ethylene carbonate, and semicarbazide hydro-semicarbazide hydrochloride were not carcinogenic under the test conditions. Dithiooxamide, glycerol α-monochlorohydrin, and thiosemicarbazide gave somewhat ambiguous results, though administered at high enough dose levels to be toxic. An inadequate number of animals survived treatments with sodium azide, sodium bisulfide, and vinylene carbonate, or the animals may not have received sufficiently high doses of the test chemicals to provide maximum test sensitivity. However, there were no indications that these three chemicals were carcinogenic under the test conditions.