MECHANISMS OF HEMOCONCENTRATION IN THE DOG DURING ACUTE ENDRIN INSECTICIDE POISONING

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Abstract
Hemoconcentration following intravenous administration of the chlorinated hydrocarbon insecticide endrin was investigated in sham-operated, splenectomized, and abdominal-eviscerated dogs. Isolated perfused lung preparations and those in which total venous return to the heart was monitored were also utilized. By 30 minutes after endrin the hematocrit had increased 14% in sham-operated animals but only 8% in splenectomized and eviscerated dogs. Blood pH fell to low levels in all groups. Pulmonary artery pressure increased in the constant flow perfused lungs after endrin; an early increase preceded a loss of lung weight. Pulmonary vascular resistance and left atrial and pulmonary artery pressures increased after endrin in the venous return studies. Hemoconcentration appears to result in part from addition of cell-rich blood from the spleen, and an increase in mean corpuscular volume secondary to the severe acidemia as observed in several experiments may also be involved. Loss of plasma fluid in the hepatosplanchnic area does not seem to occur, but pulmonary venous pressure was elevated, and loss of vascular volume from the lungs cannot be excluded.

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