PERIPHERAL VASCULAR EFFECTS OF THE INSECTICIDE ENDRIN

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Abstract
The peripheral vascular actions of insecticides are relatively unexplored. The effects of the chlorinated hydrocarbon insecticide endrin on vascular resistances were investigated in forelimbs of anesthetized dogs. Total arterial, small-vessel, and venous segmental resistances were determined in innervated and denervated limbs following lethal infusions of endrin. Limb weight was recorded continuously in some experiments. Endrin administration resulted in large increases in total limb vascular resistance, most of which were due to an increase in small-vessel (small artery to small vein) resistance. Arterial and venous segmental resistances also increased. Early responses of innervated and denervated limbs were similar. Limb blood flow decreased markedly, and when measured, limb weight fell progressively. These effects appear to result primarily from an increased level of circulating catecholamines. Hyperexcitability to noise, bradycardia, and hypertension preceded the development of systemic hypotension.