Virus membrane-fusion proteins: more than one way to make a hairpin
Top Cited Papers
- 1 January 2006
- journal article
- review article
- Published by Springer Nature in Nature Reviews Microbiology
- Vol. 4 (1) , 67-76
- https://doi.org/10.1038/nrmicro1326
Abstract
Structure-function studies have defined two classes of viral membrane-fusion proteins that have radically different architectures but adopt a similar overall 'hairpin' conformation to induce fusion of the viral and cellular membranes and therefore initiate infection. In both classes, the hairpin conformation is achieved after a conformational change is triggered by interaction with the target cell. This review will focus in particular on the properties of the more recently described class II proteins.Keywords
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