Effect of Two Types of β-Adrenergic Blockade on Gastric Acid Secretion during Basal Conditions and during Histamine Stimulation in Non-vagotomized and in Vagotomized Gastric Fistula Dogs

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Abstract
The effect of β-adrenoceptor blockade by propranolol and practolol on basal secretion and on submaximally histamine-stimulated gastric acid secretion was studied in conscious non-vagotomized and in vagotomized gastric fistula dogs. Neither propranolol (0.5 mg/kg) nor practolol (1.0 mg/kg), both intravenously, had a significant influence on basal or histamine-stimulated gastric acid secretion in non-vagotomized and vagotomized dogs. It is concluded that β-adrenergic blockade has no influence on basal or histamine-stimulated gastric acid secretion in dogs. Furthermore, no differences were found between the non-vagotomized and the vagotomized stomach.