Identification of a sequence required for efficient packaging of human immunodeficiency virus type 1 RNA into virions
- 1 September 1989
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 63 (9) , 4085-4087
- https://doi.org/10.1128/jvi.63.9.4085-4087.1989
Abstract
Sequences required for efficient packaging of human immunodeficiency virus type 1 (HIV-1) genome RNA into virus particles were identified. Deletion of 19 base pairs between the 5'' long terminal repeat and the gag gene initiation codon of HIV-1 resulted in a virus markedly attenuated for replication in human T lymphocytes. The mutant virus was characterized by nearly wild-type ability to encode viral proteins and to produce virion particles. The mutant virions exhibited a significant reduction in the content of HIV-1-specific RNA. These results identify an important component of the HIV-1 packaging signal.This publication has 18 references indexed in Scilit:
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