Chemical and biochemical studies on carbohydrate esters. VI. Further examinations on antitumor activities of stearoyl esters of sucrose.

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Abstract
A series of commercially available, nonionic surfactants produced by partial acylation of sucrose with hydrogenated beef-tallow fatty acids, i.e., the 8 kinds of DK-esters containing the mono-, di-, tri- and polyesters of stearic and palmitic acids at different ratios were tested for their antitumor effect against Ehrlich ascites carcinoma by total packed cell volume (TPCV) method. The antileukemic activity of these DK-esters, as well as of the sucrose-monostearate preparation (SS-C), was also examined by tissue culture method, using a mouse leukemia cell line L-5178Y. The monoester constituents contained in them exerted inhibitory effects against both tumors, in spite of the negative activities of the coexisting higher esters. SS-C exhibited antitumor effects on ascites sarcoma 180 implanted in mice (TPCV method and survival method), though it showed no activity against the same tumor in solid form (so-called host-mediated bioassay).