RENAL FUNCTION IN NORMAL RABBITS AND DOGS AND THE EFFECT OF URANYL SALTS

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Abstract
In the normal dog and rabbit, increase in the rate of urine flow increases the renal clearance of chloride and decreases slightly the fractional reabsorption of chloride by the tubule. In neither dog nor rabbit is the tubular secretion of diodrast a function of urine rate. In these expts. the inulin clearance appears to be a function of urine rate in the dog but not in the rabbit. In both dog and rabbit,inhalation or intraven. injn. of uranyl salts decreases the tubular secretion of diodrast and reabsorption of chloride. The inulin clearance is decreased, probably by increased permeability of the tubular membrane to water and dissolved substances. All effects lessen in magnitude during continued exposure to non-lethal amts. of uranyl salts.

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