Simultaneous absence of the human IgG1, IgG2, IgG4 and IgA1 subclasses: Immunological and immunogenetical considerations
- 1 January 1983
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 13 (3) , 240-244
- https://doi.org/10.1002/eji.1830130312
Abstract
Simultaneous absence of the IgG1, IgG2, IgG4 and IgA1 immunoglobulins has been unambiguously demonstrated in a healthy 75‐year‐old woman by testing for allotypes, isoallotypes and for isotypes of these four subclasses. Only IgM, IgD, IgG3, IgA2 and IgE were present. The IgG3 levels were significantly increased. Family investigation showed inheritance of a haplotype Gm−;−;b A2m2. This person is homozygous for an extensive DNA deletion including the Cγ1, Cγ2, Cγ4 and Cα1 genes.This publication has 33 references indexed in Scilit:
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