Gamma Globulin Antigenic Types Defined by Heavy Chain Determinants
- 10 July 1964
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 145 (3628) , 168-170
- https://doi.org/10.1126/science.145.3628.168
Abstract
Two populations of immunologically distinguishable 7S gamma globulins in normal human serum and two corresponding antigenic types of myeloma 7S gamma globulins have been detected with rabbit antiserums to proteins associated with pathological conditions, the differences being related to the H-chains of 7S gamma globulin. No relationship exists with type I and type II antigenic classification, determined by L-chains. Human serums with various hereditary gamma globulin (Gm) specificities contain both types of 7S gamma globulin.Keywords
This publication has 12 references indexed in Scilit:
- Clinical and immunochemical studies of four cases of heavy (Hγ2) chain diseaseThe American Journal of Medicine, 1964
- Heavy chain disease—A new disorder of serum γ-globulinsThe American Journal of Medicine, 1964
- PLASMA CELL MYELOMAMedicine, 1963
- Structural study of human γ-globulin through the analysis of the tryptic peptides of Bence-Jones proteinsBiochimica et Biophysica Acta, 1963
- TWO MAJOR TYPES OF NORMAL 7S γ-GLOBULINThe Journal of Experimental Medicine, 1963
- Properties of the Separated Chains of Human γ-GlobulinNature, 1963
- ANTIGENIC RELATIONSHIPS OF BENCE JONES PROTEINS, MYELOMA GLOBULINS, AND NORMAL HUMAN γ-GLOBULINThe Journal of Experimental Medicine, 1963
- Localization of Two Genetic Factors to Different Areas of γ-Globulin MoleculesScience, 1962
- THE STRUCTURAL BASIS FOR GENETIC VARIATIONS OF NORMAL HUMAN γ-GLOBULINSProceedings of the National Academy of Sciences, 1962
- ON STRUCTURAL AND FUNCTIONAL RELATIONS BETWEEN ANTIBODIES AND PROTEINS OF THE GAMMA-SYSTEMProceedings of the National Academy of Sciences, 1962