Difference in Target Organs in Carcinogenesis with a Heterocyclic Amine, 2‐Amino‐3,4‐dimethylimidazo[4,5‐f]quinoline, in Different Strains of Mice
Open Access
- 1 November 1999
- journal article
- Published by Wiley in Japanese Journal of Cancer Research
- Vol. 90 (11) , 1203-1206
- https://doi.org/10.1111/j.1349-7006.1999.tb00696.x
Abstract
2‐Amino‐3,4‐dimethylimidazo[4,5‐f]quinoline (MeIQ) induces cancers in the forestomach and liver, but not in the colon, of CDF1 male and female mice, which are thought to be resistant to induction of colon cancer by 1,2‐dimethylhydrazine. In this study, we examined the carcinogenicity of MeIQ in C57BL/6N female mice, which are susceptible to 1,2‐dimethylhydrazine. This strain of mice developed carcinomas of the cecum, colon and liver, but not the forestomach, when given a diet containing 300 ppm of MeIQ. This fact indicates that the target organs of a chemical carcinogen change depending on the strain of a given animal species.Keywords
This publication has 12 references indexed in Scilit:
- No direct correlation between mutant frequencies and cancer incidence induced by MeIQ in various organs of Big Blue® miceMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1998
- The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasiaCell, 1995
- The use of shuttle vectors for mutation analysis in transgenic mice and ratsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1994
- Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouseCell, 1993
- Carcinogenic factors in food with relevance to colon cancer developmentMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1993
- Carcinogenicities of heterocyclic amines in cooked foodMutation Research/Genetic Toxicology, 1991
- Induction of tumors in the Zymbal gland, oral cavity, colon, skin and mammary gland of F344 rats by a mutagenic compound, 2-amino-3, 4-dimethylimidazo[4, 5-f)quinolineCarcinogenesis: Integrative Cancer Research, 1989
- Induction of hepatocellular carcinoma and highly metastatic squamous cell carcinomas in the forestomach of mice by feeding 2-amino-3, 4-dimethylimidazo[4, 5-f]quinolineCarcinogenesis: Integrative Cancer Research, 1986
- Differential susceptibility of 3 sublines of C57BL6 mice to the induction of colorectal tumors by 1,2-dimethylhydrazineCancer Letters, 1980