Delayed Magnetic Resonance Hepatic Imaging with Gadolinium-DTPA

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Abstract
Nelson RC, Umpierrez ME, Chezmar JL, Bernardino ME. Delayed magnetic resonance hepatic imaging with gadolinium-DTPA. Magnetic resonance imaging of the liver was performed on 11 rabbits (3–5 kg) before and at 4, 5 and 6 hours after the intravenous administration of 0.3 mM/kg Gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) to determine if hepatocytes exhibit delayed excretion of Gd-DTPA, similar to the delayed hepatic excretion of iodinated contrast agents. Imaging was performed at 0.5 Tesla in the axial plane using a spin echo sequence of TR/TE, 250/20 milliseconds. Precontrast and postcontrast intensity changes for liver and muscle were standardized and compared over time. The average percent of postcontrast enhancement for liver and muscle, respectively was: 30.6 9.5% and 173 ± 17.0% immediately postcontrast; 9.7 ± 13.6% and 1.6 ± 13.8% at 4 hours; 9.6 ± 7.8% and 4.3 ± 13.2% at 5 hours; and 11.0 ± 7.8% and 4.1 ± 11.7% at 6 hours. We conclude that there is not significant hepatocyte excretion of Gd-DTPA at 4 to 6 hours postcontrast injection in rabbits and that this may not be an advantageous paramagnetic contrast strategy for focal hepatic lesion detection.