STUDIES ON SUPRARENAL INSUFFICIENCY

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Abstract
Repeated blood sugar determinations by the Folin micromethod on 24 normal rats, 19 suprarenalectomized rats, and 9 rats with autoplastic cortical transplants give the following results: normal fasting blood sugar range, 61 to 110 mgm. per 100 cc, average 82 mgm. Following supra-renalectomy, coincident with appearance of symptoms of subacute insufficiency, blood sugar falls to 50-60 mgm., and in terminal convulsive stages may fall as low as 30 mgm. In rats with chronic suprarenal insufficiency, the blood sugar may fall to the lowest portion of the normal range and be maintained at that level, occasionally dropping below. In rats possessing either gross accessory cortical tissue or successful cortical transplants, in the absence of demonstrable chro-maffin tissue, the blood sugar remains within the normal range. The blood sugar is normal following control blank operation. The authors suggest that the suprarenal cortex is concerned in the steady maintenance of a normal blood sugar level, while the medulla is an important adjunct for rapid adjustment under emergency conditions.

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