BIOGENESE VON ÖSTRATETRAENOL BEIM MENSCHEN

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Abstract
Incubation of androsta-4, 16-dien-3-one with 10,000 X g supernatant of human placenta tissue resulted in the formation of a phenolic metabolite. This was isolated and subsequently identified as estratetraen-3-ol by its melting point, paper chromatography, and the absorption curves of the sulfuric acid water reaction and the Kober reaction. The conversion of androsta-4, 16-dien-3-one to estratetraen-3-ol was approximately 25%, whereas under similar conditions testosterone was aromatised to estradiol-17/3 (and estrone) in a 30% yield. The significance of these results is discussed with regard to the conversion of testosterone to 16, 17-epi-estriol.