Augmentation of bladder contractility after beta-adrenergic blockade in spinal cord injured patients

Abstract
Spinal cord injured patients (6) were evaluated with cystometry, bladder electromyography and external urethal sphincter pressure profiles before and after propranolol hydrochloride administration. Bladder contractility was significantly augmented, and was associated with decreased .beta.-sympathetic bladder stimulation. The results of these clinical neurophysiological investigations suggest inhibitory influences upon the smooth muscle of the human urinary bladder via .beta.-sympathetic receptors.