The Expression of Early and Late Damage after Thoracic Irradiation: A Comparison between CBA and C57Bl Mice

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Abstract
Lung injury after localized irradiation of the thorax was quantified and compared in CBA and C57Bl mice. Using lethality and breathing rats as end points, 2 phases of damage separated in time were distinguished in CBA mice as an early pneumonitic phase and a later phase associated with pleural effusions. C57Bl mice failed to show the pneumonitic response over a large dose range extending beyond 20 Gy [Gray]. In this respect they differ from most other mouse strains so far studied. At the lower doses the extent of the late phase was similar between these 2 strains. The interstrain comparison presented suggests that damage to separate tissue compartments was responsible for the acute and chronic responses.