Epidemiological and Experimental Observations on the Possible Significance of Rodents in a Suburban Epidemic of Poliomyelitis

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Abstract
A rodent-pathogenic virus which paralyzes albino mice, cotton rats, and hamsters was isolated from the brain of a house mouse found dead in the home of a fatal case of human poliomyelitis. Another rodent-pathogenic virus capable of inducing paralysis in albino mice, cotton rats, and hamsters was isolated from the brain stem of this fatal case. The 2 viruses, when passaged in albino mice, are similar in that both are completely inactivated by antisera against Theiler''s virus of mouse encephalomyelitis and show some neutralization with convalescent sera from patients involved in this epidemic. They differ however markedly in virulence for albino mice in that the human virus is much more potent than the mouse virus.

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