A practical synthesis of 3-[(1R)-1-t-butyldimethylsilyloxyethyl]-4-[(2R)-4-halo-3-oxo-2-butyl]azetidinone, a versatile intermediate for carbapenem antibiotics

This publication has 13 references indexed in Scilit:

• General and efficient synthesis of 2-alkylcarbapenems: synthesis of dethiacarba analogs of Clinically Useful carbapenems via palladium-catalyzed cross-coupling reaction
  Tetrahedron, 1997
• Synthesis and antibacterial activity of lipophilic carbapenems with anti-MRSA activity
  Bioorganic & Medicinal Chemistry Letters, 1996
• Synthesis and Antibacterial Activity of 2-(Isoxazolidinio-5-yl)carbapenem Derivatives.
  The Journal of Antibiotics, 1995
• Synthesis and antibacterial activity of 2-functionalized-vinyl 1β-methylcarbapenems and related compounds
  Bioorganic & Medicinal Chemistry Letters, 1993
• Stability of meropenem and effect of 1 beta-methyl substitution on its stability in the presence of renal dehydropeptidase I
  Antimicrobial Agents and Chemotherapy, 1992
• Carbapenem and penem antibiotics. VII. Synthesis and antibacterial activity of 1.BETA.-methyl-2-(quaternary heteroaromatic-thiomethyl) carbapenems.
  CHEMICAL & PHARMACEUTICAL BULLETIN, 1991
• The synthesis of 2-(functionalized methyl)-1.BETA.-methylcarbapenems.
  The Journal of Antibiotics, 1988
• Highly regioselective formation of bromohydrins by reaction of epoxy-azetidinones with MgBr2: An alternative route to 4-bromomethylcarbonylmethyl-2-azetidinone, a key carbapenem precursor
  Tetrahedron Letters, 1988
• Carbapenem and penem antibiotics. IV. Synthesis and antibacterial activity of (5R*,6S*)-6-((R*)-1-hydroxyethyl)-2-functionalized-methyl carbapenem and penem derivatives.
  CHEMICAL & PHARMACEUTICAL BULLETIN, 1985
• Synthetic Carbapenem Antibiotics. I. 1-b-Methylcarbapenem
  HETEROCYCLES, 1984