GLUCOSE-UPTAKE AND INSULIN SECRETORY RESPONSES TO INTRAVENOUS GLUCOSE LOADS IN THE DOG

  • 1 January 1981
    • journal article
    • research article
    • Vol. 42  (1) , 155-158
Abstract
Healthy young nonanesthetized Dalmatian dogs (10 male, 11 female) were given I.V. glucose loads between 300 and 1500 mg/kg of body wt in a standard time period of 30 s. The fractional glucose turnover rates and the insulin peak responses gradually increased with glucose loads up to 1,000 mg/kg, and the total insulin secretion with loads to 1250 mg/kg and remained constant. The insulinogenic index (.DELTA.insulin/.DELTA.glucose) varied inversely with the size of the glucose loads. The pattern of responses indicates that the optimum glucose load is near 600 mg/kg for evaluating normal glucose metabolism in dogs by the I.V. glucose loading technique.